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Process Optimization: From Route
to Lab Process
From route to lab process, Chemrio optimizes the feasible
route into a viable laboratory process. Depending on our
clients' need for support, we develop quantitative analytical
methods for in-process controls, determine and optimize
the critical parameters in the process, and optimize the
work-up procedures.
Our goal: To develop a viable process for production at
the pilot-plant scale, and provide the first multi-gram
amounts of the target API.
At a minimum you can anticipate the following outcomes
as a result of input combined with our activities:
Input
 Feasible
route
Qualitative
analytic data (e.g. NMR, IR, UV, MS etc.)
Activities
Evaluation
of alternate conditions
Stability
testing
Critical
parameters determination (DOE)
Work-up
optimisation
Analytical
method development
Output
Laboratory
process
Detailed report o IPCs
Quantitative analytical data (e.g. NMR, IR, UV, MS etc.)
Samples
and/or references o Multi gram amounts
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